5ineHTPÒ  is mostly effective in low serotonin states as listed below:

• Depression
• Obesity
• Carbohydrate craving/ Bulimia
• Insomnia
• Narcolepsy / Addictive Patterns
• Sleep apnoea Migraine headaches
• Tension headaches Chronic daily headaches
• Premenstrual syndrome
• Fibromyalgia

Serotonin deficiency has also been implicated in uncontrollable appetite, obsessive-compulsive disorder(OCD), autism, social phobias, anxiety and panic, migraines, schizophrenia and extreme violence.